Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Murillo P
PROVIDER: S-EPMC4921460 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Martinez-Murillo Paola P Pramanik Lotta L Sundling Christopher C Hultenby Kjell K Wretenberg Per P Spångberg Mats M Karlsson Hedestam Gunilla B GB
Frontiers in immunology 20160627
Plasma cells (PCs) are defined as terminally differentiated B cells that secrete large amounts of immunoglobulin (Ig). PCs that reside in the bone marrow (BM) are responsible for maintaining long-term antibody (Ab) responses after infection and vaccination, while PCs present in the blood are generally short-lived. In rhesus macaques, a species frequently used for the evaluation of human vaccines, B cells resemble those found in humans. However, a detailed characterization of BM-resident rhesus P ...[more]