Ontology highlight
ABSTRACT:
SUBMITTER: Saha A
PROVIDER: S-EPMC4922691 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Saha Asim A O'Connor Roddy S RS Thangavelu Govindarajan G Lovitch Scott B SB Dandamudi Durga Bhavani DB Wilson Caleph B CB Vincent Benjamin G BG Tkachev Victor V Pawlicki Jan M JM Furlan Scott N SN Kean Leslie S LS Aoyama Kazutoshi K Taylor Patricia A PA Panoskaltsis-Mortari Angela A Foncea Rocio R Ranganathan Parvathi P Devine Steven M SM Burrill Joel S JS Guo Lili L Sacristan Catarina C Snyder Nathaniel W NW Blair Ian A IA Milone Michael C MC Dustin Michael L ML Riley James L JL Bernlohr David A DA Murphy William J WJ Fife Brian T BT Munn David H DH Miller Jeffrey S JS Serody Jonathan S JS Freeman Gordon J GJ Sharpe Arlene H AH Turka Laurence A LA Blazar Bruce R BR
The Journal of clinical investigation 20160613 7
Programmed death ligand-1 (PD-L1) interaction with PD-1 induces T cell exhaustion and is a therapeutic target to enhance immune responses against cancer and chronic infections. In murine bone marrow transplant models, PD-L1 expression on host target tissues reduces the incidence of graft-versus-host disease (GVHD). PD-L1 is also expressed on T cells; however, it is unclear whether PD-L1 on this population influences immune function. Here, we examined the effects of PD-L1 modulation of T cell fun ...[more]