Ontology highlight
ABSTRACT:
SUBMITTER: Saha A
PROVIDER: S-EPMC6795410 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Saha Asim A Taylor Patricia A PA Lees Christopher J CJ Panoskaltsis-Mortari Angela A Osborn Mark J MJ Feser Colby J CJ Thangavelu Govindarajan G Melchinger Wolfgang W Refaeli Yosef Y Hill Geoffrey R GR Munn David H DH Murphy William J WJ Serody Jonathan S JS Maillard Ivan I Kreymborg Katharina K van den Brink Marcel M Dong Chen C Huang Shuyu S Zang Xingxing X Allison James P JP Zeiser Robert R Blazar Bruce R BR
JCI insight 20191003 19
B7-H4 is a negative regulatory B7 family member. We investigated the role of host and donor B7-H4 in regulating acute graft-versus-host disease (GVHD). Allogeneic donor T cells infused into B7-H4-/- versus WT recipients markedly accelerated GVHD-induced lethality. Chimera studies pointed toward B7-H4 expression on host hematopoietic cells as more critical than parenchymal cells in controlling GVHD. Rapid mortality in B7-H4-/- recipients was associated with increased donor T cell expansion, gut T ...[more]