Ontology highlight
ABSTRACT:
SUBMITTER: Miller B
PROVIDER: S-EPMC4922697 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Miller Bradley B Palygin Oleg O Rufanova Victoriya A VA Chong Andrew A Lazar Jozef J Jacob Howard J HJ Mattson David D Roman Richard J RJ Williams Jan M JM Cowley Allen W AW Geurts Aron M AM Staruschenko Alexander A Imig John D JD Sorokin Andrey A
The Journal of clinical investigation 20160606 7
Renal preglomerular arterioles regulate vascular tone to ensure a large pressure gradient over short distances, a function that is extremely important for maintaining renal microcirculation. Regulation of renal microvascular tone is impaired in salt-sensitive (SS) hypertension-induced nephropathy, but the molecular mechanisms contributing to this impairment remain elusive. Here, we assessed the contribution of the SH2 adaptor protein p66Shc (encoded by Shc1) in regulating renal vascular tone and ...[more]