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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

ABSTRACT: We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20?ppm in feed) or Reporcin (recombinant growth hormone; GH; 10?mg/48?hours injected) and compared to a control cohort (feed only; no injections) over a 27-day time course (1, 3, 7, 13 or 27-days). Longissimus Dorsi muscle gene expression was analyzed using Agilent porcine transcriptome microarrays and clusters of genes displaying similar expression profiles were identified using a modified maSigPro clustering algorithm. Anabolic agents increased carcass (p?=?0.002) and muscle weights (Vastus Lateralis: p?

SUBMITTER: Brown DM 

PROVIDER: S-EPMC4923900 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

Brown D M DM   Williams H H   Ryan K J P KJ   Wilson T L TL   Daniel Z C T R ZC   Mareko M H D MH   Emes R D RD   Harris D W DW   Jones S S   Wattis J A D JA   Dryden I L IL   Hodgman T C TC   Brameld J M JM   Parr T T  

Scientific reports 20160628

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombinant growth hormone; GH; 10 mg/48 hours injected) and compared to a control cohort (feed only; no injections) over a 27-day time course (1, 3, 7, 13 or 27-days). Longissimus Dorsi muscle gene expression was analyzed using Agilent porcine transcriptom  ...[more]

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