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Salvianolic Acid B Inhibits A? Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells.


ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-? (A?) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate A?-induced memory impairment. However, whether SalB could influence the generation of A? is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of A?40 and A?42 in culture media by decreasing the protein expressions of BACE1 and sAPP? in SH-SY5Y-APPsw cells. Meanwhile, SalB increases the levels of ADAM10 and sAPP? in the cells. However, SalB has no impact on the protein expressions of APP and PS1. Moreover, SalB attenuates oxidative stress and inhibits the activity of GSK3?, which might be related to the suppression of BACE1 expression and amyloidogenesis. Our study suggests that SalB is a promising therapeutic agent for AD by targeting A? generation.

SUBMITTER: Tang Y 

PROVIDER: S-EPMC4924174 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells.

Tang Ying Y   Huang Dan D   Zhang Mei-Hua MH   Zhang Wen-Sheng WS   Tang Yu-Xin YX   Shi Zheng-Xiang ZX   Deng Li L   Zhou Dai-Han DH   Lu Xin-Yi XY  

Nutrients 20160601 6


Alzheimer's disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-β (Aβ) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB could influence the generation of Aβ is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of Aβ40 and Aβ42 in culture media by decreasing the protein expressions of BACE1 and sAPPβ in SH-SY5Y-APPs  ...[more]

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