Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC4924174 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tang Ying Y Huang Dan D Zhang Mei-Hua MH Zhang Wen-Sheng WS Tang Yu-Xin YX Shi Zheng-Xiang ZX Deng Li L Zhou Dai-Han DH Lu Xin-Yi XY
Nutrients 20160601 6
Alzheimer's disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-β (Aβ) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB could influence the generation of Aβ is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of Aβ40 and Aβ42 in culture media by decreasing the protein expressions of BACE1 and sAPPβ in SH-SY5Y-APPs ...[more]