Ontology highlight
ABSTRACT:
SUBMITTER: O'Hagan-Wong K
PROVIDER: S-EPMC4924641 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Oncotarget 20160301 12
Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallmark of cellular aging, occurs in aged MSC. Whether MSC aging alters the bone marrow niche triggering HSPC dysfunction is unknown. Using a human MSC-HSPC co-culture system, we demonstrated that DNA dam ...[more]