Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC4924644 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cao Lei L Wang Hui-Fu HF Tan Lin L Sun Fu-Rong FR Tan Meng-Shan MS Tan Chen-Chen CC Jiang Teng T Yu Jin-Tai JT Tan Lan L
Oncotarget 20160301 12
Alzheimer's disease (AD) has become a considerable public health issue. The mechanisms underlying AD onset and progression remain largely unclear. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is a strong functional AD candidate gene because it encodes part of the statin-binding domain of the enzyme, which serves as the rate-limiting step in cholesterol synthesis in all mammalian cells. Here, we evaluated the potential role of HMGCR (rs3846662) in AD-related pathology by assessing neur ...[more]