Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC4924726 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhu Yu Y Zhang Xuebin X Qi Lisha L Cai Ying Y Yang Ping P Xuan Geng G Jiang Yuan Y
Oncotarget 20160301 12
Tumor angiogenesis plays a critical role in the tumor progression. Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA) that acts as an oncogene in gliomas. We found that HULC, vascular endothelial growth factor (VEGF), and ESM-1 (endothelial cell specific molecule 1) expression and microvessel density were positively correlated with grade dependency in glioma patient tissues, and that HULC silencing suppressed angiogenesis by inhibiting glioma cells proliferation and invas ...[more]