Ontology highlight
ABSTRACT:
SUBMITTER: Lee DH
PROVIDER: S-EPMC4925102 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Lee Dhong Hyun DH Thoennissen Nils H NH Goff Catherine C Iwanski Gabriela B GB Forscher Charles C Doan Ngan B NB Said Jonathan W JW Koeffler H Phillip HP
Cancer letters 20110326 2
We investigated the use of cucurbitacin B, a plant-derived tetracyclic triterpenoid, as a single agent or in combination with methotrexate (MTX) for human osteosarcoma (OS) treatment. Cucurbitacin B showed antiproliferative activity against seven human OS cell lines in vitro accompanying G2/M cell cycle arrest, apoptosis, and inhibition of ERK, Akt, and mTOR proteins. Cucurbitacin B in combination with MTX synergistically inhibited OS cell growth in vitro. Low-dose cucurbitacin B (LD-CuB, 0.5 mg ...[more]