Ontology highlight
ABSTRACT:
SUBMITTER: Rowland LA
PROVIDER: S-EPMC4925282 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Rowland Leslie A LA Maurya Santosh K SK Bal Naresh C NC Kozak Leslie L Periasamy Muthu M
Obesity (Silver Spring, Md.) 20160530 7
<h4>Objective</h4>It is well known that uncoupling protein 1 (UCP1) in brown adipose tissue plays an important role in diet-induced thermogenesis. In this study, whether sarcolipin (SLN), a regulator of sarco/endoplasmic reticulum Ca(2+) -ATPase pump in muscle, is also an important player of diet-induced thermogenesis was investigated, as well as whether loss of SLN could be compensated by increased UCP1 expression and vice versa.<h4>Methods</h4>Age- and sex-matched UCP1(-/-) , SLN(-/-) , and do ...[more]