Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer.
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ABSTRACT:
SUBMITTER: Azim S
PROVIDER: S-EPMC4926062 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer.
Azim Shafquat S Zubair Haseeb H Srivastava Sanjeev K SK Bhardwaj Arun A Zubair Asif A Ahmad Aamir A Singh Seema S Khushman Moh'd M Singh Ajay P AP
Scientific reports 20160629
We have recently demonstrated that the transcription factor MYB can modulate several cancer-associated phenotypes in pancreatic cancer. In order to understand the molecular basis of these MYB-associated changes, we conducted deep-sequencing of transcriptome of MYB-overexpressing and -silenced pancreatic cancer cells, followed by in silico pathway analysis. We identified significant modulation of 774 genes upon MYB-silencing (p < 0.05) that were assigned to 25 gene networks by in silico analysis. ...[more]
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