Dataset Information

MYB-regulated pancreatic cancer secretome

ABSTRACT: Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the secretome from MYB-modulated and control pancreatic cancer cell lines. We also performed in silico analyses to determine MYB-associated biofunctions, gene networks and altered biological pathways. We further investigated the secreted proteins for their potential biomarker properties.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Pancreatic Ductal Carcinoma

SUBMITTER: Ajay Singh

LAB HEAD: Dr. Ajay P Singh

PROVIDER: PXD015126 | Pride | 2021-09-08

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Mascotfileforproteinsidentified.xlsx	Xlsx
	as_011217_bxp_myb_1.raw	Raw
	as_011217_bxp_myb_2.raw	Raw
	as_011217_bxp_myb_3.raw	Raw
	as_011217_bxp_neo_1.raw	Raw

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Publications

Proteomic Analysis of MYB-Regulated Secretome Identifies Functional Pathways and Biomarkers: Potential Pathobiological and Clinical Implications.

Zubair Haseeb H Patel Girijesh Kumar GK Khan Mohammad Aslam MA Azim Shafquat S Zubair Asif A Singh Seema S Srivastava Sanjeev Kumar SK Singh Ajay Pratap AP

Journal of proteome research 20200127 2

Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the secretome from MYB-modulated and control pancreatic cancer cell lines. We also performed in silico analyses to determine MYB-associated biofunctions, gene networks, and altered biological pathways. Our data demonstrated significant modulation (<i>p</ ...[more]

PMID: 31928012

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