Ontology highlight
ABSTRACT:
SUBMITTER: Shimkin KW
PROVIDER: S-EPMC4927086 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Organic letters 20160211 5
Copper catalysis now enables the efficient C-alkylation of nitroalkanes with α-bromonitriles. Using a simple and inexpensive catalyst, this process provides access to β-cyanonitroalkanes. The method is highly tolerant of various functional groups and substitution patterns. These functionally dense products serve as orthogonally masked 1,3-diamines, which can be revealed selectively for access to differentially substituted diamines. These products can also be exploited for the formation of comple ...[more]