Unknown

Dataset Information

0

Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched ?-Nitroamides.

ABSTRACT: A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched ?-nitroamides from readily available ?-bromoamides using mild reaction conditions that are compatible with a wide range of functional groups. When combined with subsequent reactions, this method allows access to highly enantioenriched products with nitrogen-bearing fully substituted carbon centers.

SUBMITTER: Devannah V 

PROVIDER: S-EPMC6547819 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides.

Devannah Vijayarajan V   Sharma Rajgopal R   Watson Donald A DA  

Journal of the American Chemical Society 20190517 21

A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched β-nitroamides from readily available α-bromoamides using mild reaction conditions that are compatible with a wide range of functional groups. When combined with subsequent reactions, this method allows access to highly enantioenriched products with nitrogen-bearing fully substituted carbon centers. ...[more]

Similar Datasets

Unknown Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides.
| S-EPMC5531607 | biostudies-literature
Unknown Copper-Catalyzed Alkylation of Nitroalkanes with ?-Bromonitriles: Synthesis of ?-Cyanonitroalkanes.
| S-EPMC4927086 | biostudies-literature
Unknown Solvent-free synthesis of enantioenriched β-silyl nitroalkanes under organocatalytic conditions.
| S-EPMC8561140 | biostudies-literature
Unknown An Entry to Enantioenriched 3,3-Disubstituted Phthalides through Asymmetric Phase-Transfer-Catalyzed γ-Alkylation.
| S-EPMC8007094 | biostudies-literature
Unknown Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling.
| S-EPMC5851001 | biostudies-literature
Unknown Nickel-Catalyzed Borylation of Benzylic Ammonium Salts: Stereospecific Synthesis of Enantioenriched Benzylic Boronates.
| S-EPMC4809423 | biostudies-literature
Unknown Benzylation of nitroalkanes using copper-catalyzed thermal redox catalysis: toward the facile C-alkylation of nitroalkanes.
| S-EPMC3389751 | biostudies-literature
Unknown Nickel/bis(oxazoline)-catalyzed asymmetric Negishi arylations of racemic secondary benzylic electrophiles to generate enantioenriched 1,1-diarylalkanes.
| S-EPMC3869004 | biostudies-literature
Unknown Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylation and ruthenium-catalyzed cycloisomerization.
| S-EPMC7772093 | biostudies-literature
Unknown Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation.
| S-EPMC7803749 | biostudies-literature