Ontology highlight
ABSTRACT:
SUBMITTER: Loucks CM
PROVIDER: S-EPMC4927285 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Loucks Catrina M CM Bialas Nathan J NJ Dekkers Martijn P J MP Walker Denise S DS Grundy Laura J LJ Li Chunmei C Inglis P Nick PN Kida Katarzyna K Schafer William R WR Blacque Oliver E OE Jansen Gert G Leroux Michel R MR
Molecular biology of the cell 20160518 13
Cilia are microtubule-based organelles that project from nearly all mammalian cell types. Motile cilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and modulate various signal transduction pathways. Here we investigate the nonmotile ciliary signaling roles of parkin coregulated gene (PACRG), a protein linked to ciliary motility. PACRG is associated with the protofilament ribbon, a structure believed to dictate the regular arrangement of motility-asso ...[more]