Ontology highlight
ABSTRACT:
SUBMITTER: Hofherr A
PROVIDER: S-EPMC6095617 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hofherr Alexis A Seger Claudia C Fitzpatrick Fiona F Busch Tilman T Michel Elisabeth E Luan Jingting J Osterried Lea L Linden Frieder F Kramer-Zucker Albrecht A Wakimoto Barbara B Schütze Conny C Wiedemann Nils N Artati Anna A Adamski Jerzy J Walz Gerd G Kunji Edmund R S ERS Montell Craig C Watnick Terry T Köttgen Michael M
PLoS biology 20180806 8
Cilia are organelles specialized in movement and signal transduction. The ciliary transient receptor potential ion channel polycystin-2 (TRPP2) controls elementary cilia-mediated physiological functions ranging from male fertility and kidney development to left-right patterning. However, the molecular components translating TRPP2 channel-mediated Ca2+ signals into respective physiological functions are unknown. Here, we show that the Ca2+-regulated mitochondrial ATP-Mg/Pi solute carrier 25 A 25 ...[more]