Ontology highlight
ABSTRACT:
SUBMITTER: Teich AF
PROVIDER: S-EPMC4927884 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Teich Andrew F AF Sakurai Mikako M Patel Mitesh M Holman Cameron C Saeed Faisal F Fiorito Jole J Arancio Ottavio O
Journal of Alzheimer's disease : JAD 20160101 1
Phosphodiesterase 5 (PDE5) is a critical component of the cGMP-PKG axis of cellular signaling in neurons, and inhibition of PDE5 has been shown to be therapeutic in a wide range of neurologic conditions in animal models. However, enthusiasm for PDE5 inhibitors in humans is limited by data suggesting that PDE5 may not exist in human neurons. Here, we first show that past attempts to quantify PDE5 mRNA were flawed due to the use of incorrect primers, and that when correct primers are used, PDE5 mR ...[more]