Ontology highlight
ABSTRACT:
SUBMITTER: Schokrpur S
PROVIDER: S-EPMC4928183 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Schokrpur Shiruyeh S Hu Junhui J Moughon Diana L DL Liu Peijun P Lin Lucia C LC Hermann Kip K Mangul Serghei S Guan Wei W Pellegrini Matteo M Xu Hua H Wu Lily L
Scientific reports 20160630
Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α) is well-studied. Recent work has demonstrated that VHL knock down induces an epithelial-mesenchymal transition (EMT) phenotype. In this study we showed that a CRISPR/Cas9-mediated knock out of V ...[more]