A Meta-Analysis of Executive Dysfunction and Antidepressant Treatment Response in Late-Life Depression.

ABSTRACT:

Objective

Depressed older adults with executive dysfunction (ED) may respond poorly to antidepressant treatment. ED is a multifaceted construct and different studies have measured different aspects of ED, making it unclear which aspects predict poor response. Meta-analytic methods were used to determine whether ED predicts poor antidepressant treatment response in late-life depression and to determine which domains of executive functioning are responsible for this relationship.

Methods

A Medline search was conducted to identify regimented treatment trials contrasting executive functioning between elderly responders and nonresponders; only regimented treatment trials for depressed outpatients aged 50 and older were included. Following the most recent PRISMA guidelines, 25 mea

SUBMITTER: Pimontel MA 

PROVIDER: S-EPMC4928373 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature