Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Cano J
PROVIDER: S-EPMC4928511 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
García-Cano Jesús J Roche Olga O Cimas Francisco J FJ Pascual-Serra Raquel R Ortega-Muelas Marta M Fernández-Aroca Diego M DM Sánchez-Prieto Ricardo R
Frontiers in cell and developmental biology 20160630
The p38MAPK signaling pathway was initially described as a stress response mechanism. In fact, during previous decades, it was considered a pathway with little interest in oncology especially in comparison with other MAPKs such as ERK1/2, known to be target of oncogenes like Ras. However, its involvement in apoptotic cell death phenomena makes this signaling pathway more attractive for many cancer research laboratories. This apoptotic role allows to establish a link between p38MAPK and regular c ...[more]