IL-1 Family Members in Cancer; Two Sides to Every Story.
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ABSTRACT:
SUBMITTER: Baker KJ
PROVIDER: S-EPMC6567883 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
IL-1 Family Members in Cancer; Two Sides to Every Story.
Baker Kevin J KJ Houston Aileen A Brint Elizabeth E
Frontiers in immunology 20190607
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of ...[more]
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