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Effective molarity in a nucleic acid-controlled reaction.

ABSTRACT: Positioning of reactive functional groups within a DNA duplex can enable chemical reactions that otherwise would not occur to an appreciable extent. However, few studies have quantitatively defined the extent to which the enforced proximity of reaction partners in duplex DNA can favor chemical processes. Here, we measured substantial effective molarities (as high as 25M) afforded by duplex DNA to a reaction involving interstrand cross-link formation between 2'-deoxyadenosine and a 2-deoxyribose abasic (Ap) site.

SUBMITTER: Catalano MJ

PROVIDER: S-EPMC4928584 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Effective molarity in a nucleic acid-controlled reaction.

Catalano Michael J MJ Price Nathan E NE Gates Kent S KS

Bioorganic & medicinal chemistry letters 20160409 11

Positioning of reactive functional groups within a DNA duplex can enable chemical reactions that otherwise would not occur to an appreciable extent. However, few studies have quantitatively defined the extent to which the enforced proximity of reaction partners in duplex DNA can favor chemical processes. Here, we measured substantial effective molarities (as high as 25M) afforded by duplex DNA to a reaction involving interstrand cross-link formation between 2'-deoxyadenosine and a 2-deoxyribose ...[more]

PMID: 27117430

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