Ontology highlight
ABSTRACT:
SUBMITTER: Kemper K
PROVIDER: S-EPMC4929150 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Kemper Kristel K Krijgsman Oscar O Kong Xiangjun X Cornelissen-Steijger Paulien P Shahrabi Aida A Weeber Fleur F van der Velden Daphne L DL Bleijerveld Onno B OB Kuilman Thomas T Kluin Roel J C RJC Sun Chong C Voest Emile E EE Ju Young Seok YS Schumacher Ton N M TNM Altelaar A F Maarten AFM McDermott Ultan U Adams David J DJ Blank Christian U CU Haanen John B JB Peeper Daniel S DS
Cell reports 20160616 1
The therapeutic landscape of melanoma is improving rapidly. Targeted inhibitors show promising results, but drug resistance often limits durable clinical responses. There is a need for in vivo systems that allow for mechanistic drug resistance studies and (combinatorial) treatment optimization. Therefore, we established a large collection of patient-derived xenografts (PDXs), derived from BRAF(V600E), NRAS(Q61), or BRAF(WT)/NRAS(WT) melanoma metastases prior to treatment with BRAF inhibitor and ...[more]