Ontology highlight
ABSTRACT:
SUBMITTER: Benjamin JT
PROVIDER: S-EPMC4929391 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Benjamin John T JT van der Meer Riet R Im Amanda M AM Plosa Erin J EJ Zaynagetdinov Rinat R Burman Ankita A Havrilla Madeline E ME Gleaves Linda A LA Polosukhin Vasiliy V VV Deutsch Gail H GH Yanagisawa Hiromi H Davidson Jeffrey M JM Prince Lawrence S LS Young Lisa R LR Blackwell Timothy S TS
The American journal of pathology 20160512 7
The highly orchestrated interactions between the epithelium and mesenchyme required for normal lung development can be disrupted by perinatal inflammation in preterm infants, although the mechanisms are incompletely understood. We used transgenic (inhibitory κB kinase β transactivated) mice that conditionally express an activator of the NF-κB pathway in airway epithelium to investigate the impact of epithelial-derived inflammation during lung development. Epithelial NF-κB activation selectively ...[more]