Ontology highlight
ABSTRACT:
SUBMITTER: Plosa EJ
PROVIDER: S-EPMC7098727 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Plosa Erin J EJ Benjamin John T JT Sucre Jennifer M JM Gulleman Peter M PM Gleaves Linda A LA Han Wei W Kook Seunghyi S Polosukhin Vasiliy V VV Haake Scott M SM Guttentag Susan H SH Young Lisa R LR Pozzi Ambra A Blackwell Timothy S TS Zent Roy R
JCI insight 20200130 2
Integrins, the extracellular matrix receptors that facilitate cell adhesion and migration, are necessary for organ morphogenesis; however, their role in maintaining adult tissue homeostasis is poorly understood. To define the functional importance of β1 integrin in adult mouse lung, we deleted it after completion of development in type 2 alveolar epithelial cells (AECs). Aged β1 integrin-deficient mice exhibited chronic obstructive pulmonary disease-like (COPD-like) pathology characterized by em ...[more]