Ontology highlight
ABSTRACT:
SUBMITTER: Kwon J
PROVIDER: S-EPMC4929831 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kwon Jaeyul J Wang Aibing A Burke Devin J DJ Boudreau Howard E HE Lekstrom Kristen J KJ Korzeniowska Agnieszka A Sugamata Ryuichi R Kim Yong-Soo YS Yi Liang L Ersoy Ilker I Jaeger Stefan S Palaniappan Kannappan K Ambruso Daniel R DR Jackson Sharon H SH Leto Thomas L TL
Free radical biology & medicine 20160414
Nox1 is an abundant source of reactive oxygen species (ROS) in colon epithelium recently shown to function in wound healing and epithelial homeostasis. We identified Peroxiredoxin 6 (Prdx6) as a novel binding partner of Nox activator 1 (Noxa1) in yeast two-hybrid screening experiments using the Noxa1 SH3 domain as bait. Prdx6 is a unique member of the Prdx antioxidant enzyme family exhibiting both glutathione peroxidase and phospholipase A2 activities. We confirmed this interaction in cells over ...[more]