Ontology highlight
ABSTRACT:
SUBMITTER: Estrada J
PROVIDER: S-EPMC4930556 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Estrada Javier J Estrada Javier J Wong Felix F DePace Angela A Gunawardena Jeremy J
Cell 20160601 1
The quantitative concepts used to reason about gene regulation largely derive from bacterial studies. We show that this bacterial paradigm cannot explain the sharp expression of a canonical developmental gene in response to a regulating transcription factor (TF). In the absence of energy expenditure, with regulatory DNA at thermodynamic equilibrium, information integration across multiple TF binding sites can generate the required sharpness, but with strong constraints on the resultant "higher-o ...[more]