Ontology highlight
ABSTRACT:
SUBMITTER: van Wilgenburg B
PROVIDER: S-EPMC4931007 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
van Wilgenburg Bonnie B Scherwitzl Iris I Hutchinson Edward C EC Leng Tianqi T Kurioka Ayako A Kulicke Corinna C de Lara Catherine C Cole Suzanne S Vasanawathana Sirijitt S Limpitikul Wannee W Malasit Prida P Young Duncan D Denney Laura L Moore Michael D MD Fabris Paolo P Giordani Maria Teresa MT Oo Ye Htun YH Laidlaw Stephen M SM Dustin Lynn B LB Ho Ling-Pei LP Thompson Fiona M FM Ramamurthy Narayan N Mongkolsapaya Juthathip J Willberg Christian B CB Screaton Gavin R GR Klenerman Paul P
Nature communications 20160623
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activ ...[more]