Ontology highlight
ABSTRACT:
SUBMITTER: Barrow-McGee R
PROVIDER: S-EPMC4931016 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Barrow-McGee Rachel R Kishi Naoki N Joffre Carine C Ménard Ludovic L Hervieu Alexia A Bakhouche Bakhouche A BA Noval Alejandro J AJ Mai Anja A Guzmán Camilo C Robbez-Masson Luisa L Iturrioz Xavier X Hulit James J Brennan Caroline H CH Hart Ian R IR Parker Peter J PJ Ivaska Johanna J Kermorgant Stéphanie S
Nature communications 20160623
Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met, from inside the cell, to promote anchorage-independent cell survival. Thus, c-Met and β1-integrin co-internalize and become progressively recruited on LC3B-positive 'autophagy-related endomembranes' (ARE). In cells growing in suspension, β1-integrin promotes sustained c-Met-dependent ERK1/2 phosphorylation on ARE. This ...[more]