Ontology highlight
ABSTRACT:
SUBMITTER: Shostak A
PROVIDER: S-EPMC4931031 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Shostak Anton A Ruppert Bianca B Ha Nati N Bruns Philipp P Toprak Umut H UH Eils Roland R Schlesner Matthias M Diernfellner Axel A Brunner Michael M
Nature communications 20160624
The circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC in U2OS cells attenuates the clock and conversely promotes cell proliferation while downregulation of MYC strengthens the clock and reduces proliferation. Inhibition of the circadian clock is crucially dependent on the formation of repressive complexes of MYC w ...[more]