Ontology highlight
ABSTRACT:
SUBMITTER: Jangi S
PROVIDER: S-EPMC4931233 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Jangi Sushrut S Gandhi Roopali R Cox Laura M LM Li Ning N von Glehn Felipe F Yan Raymond R Patel Bonny B Mazzola Maria Antonietta MA Liu Shirong S Glanz Bonnie L BL Cook Sandra S Tankou Stephanie S Stuart Fiona F Melo Kirsy K Nejad Parham P Smith Kathleen K Topçuolu Begüm D BD Holden James J Kivisäkk Pia P Chitnis Tanuja T De Jager Philip L PL Quintana Francisco J FJ Gerber Georg K GK Bry Lynn L Weiner Howard L HL
Nature communications 20160628
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and ...[more]