Adjusting for age improves identification of gut microbiome alterations in multiple diseases.
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ABSTRACT:
SUBMITTER: Ghosh TS
PROVIDER: S-EPMC7065848 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Adjusting for age improves identification of gut microbiome alterations in multiple diseases.
Ghosh Tarini S TS Das Mrinmoy M Jeffery Ian B IB O'Toole Paul W PW
eLife 20200311
Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-microbiome associations display specific age-centric trends. Ageing-associated microbiome alterations towards a disease-like configuration occur in colorectal cancer patients, there ...[more]
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