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Adjusting for age improves identification of gut microbiome alterations in multiple diseases.


ABSTRACT: Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-microbiome associations display specific age-centric trends. Ageing-associated microbiome alterations towards a disease-like configuration occur in colorectal cancer patients, thereby masking disease signatures. We identified a microbiome disease response shared across multiple diseases in elderly subjects that is distinct from that in young/middle-aged individuals, but also a novel set of taxa consistently gained in disease across all age groups. A subset of these taxa was associated with increased frailty in subjects from the ELDERMET cohort. The relevant taxa differentially encode specific functions that are known to have disease associations.

SUBMITTER: Ghosh TS 

PROVIDER: S-EPMC7065848 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Adjusting for age improves identification of gut microbiome alterations in multiple diseases.

Ghosh Tarini S TS   Das Mrinmoy M   Jeffery Ian B IB   O'Toole Paul W PW  

eLife 20200311


Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-microbiome associations display specific age-centric trends. Ageing-associated microbiome alterations towards a disease-like configuration occur in colorectal cancer patients, there  ...[more]

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