Ontology highlight
ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC4931238 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature communications 20160628
Structures of BG505 SOSIP.664 trimer in complex with broadly neutralizing antibodies (bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1. Presentation of trimeric HIV-1 antigens on nanoparticles may thus provide promising vaccine candidates. Here we report the rational design, structural analysis and antigenic evaluation of HIV-1 trimer-presenting nanoparticles. We first demonstrate that both V1V2 and gp120 can be presented in native-like trimeric conforma ...[more]