MiR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.
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ABSTRACT:
SUBMITTER: Badal SS
PROVIDER: S-EPMC4931323 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.
Badal Shawn S SS Wang Yin Y Long Jianyin J Corcoran David L DL Chang Benny H BH Truong Luan D LD Kanwar Yashpal S YS Overbeek Paul A PA Danesh Farhad R FR
Nature communications 20160628
How the kidney responds to the metabolic cues from the environment remains a central question in kidney research. This question is particularly relevant to the pathogenesis of diabetic nephropathy (DN) in which evidence suggests that metabolic events in podocytes regulate chromatin structure. Here, we show that miR-93 is a critical metabolic/epigenetic switch in the diabetic milieu linking the metabolic state to chromatin remodelling. Mice with inducible overexpression of a miR-93 transgene excl ...[more]
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