Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC4931326 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature communications 20160630
Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted design of new drugs. However, by shifting the profile of β-tubulin isoforms, cancer cells become resistant to treatment. Compounds that bind to α-tubulin are less well characterized and unexploited. The natural product pironetin is known to bind to ...[more]