Ontology highlight
ABSTRACT:
SUBMITTER: Aghajanian H
PROVIDER: S-EPMC4931334 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Aghajanian Haig H Cho Young Kuk YK Manderfield Lauren J LJ Herling Madison R MR Gupta Mudit M Ho Vivienne C VC Li Li L Degenhardt Karl K Aharonov Alla A Tzahor Eldad E Epstein Jonathan A JA
Nature communications 20160630
Organogenesis and regeneration require coordination of cellular proliferation, regulated in part by secreted growth factors and cognate receptors, with tissue nutrient supply provided by expansion and patterning of blood vessels. Here we reveal unexpected combinatorial integration of a growth factor co-receptor with a heterodimeric partner and ligand known to regulate angiogenesis and vascular patterning. We show that ErbB2, which can mediate epidermal growth factor (EGF) and neuregulin signalli ...[more]