Dataset Information

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

ABSTRACT:

Background

Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.

Methods

Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years.

Results

In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively.

Conclusion

In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

SUBMITTER: Cannioto RA

PROVIDER: S-EPMC4931371 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Cannioto Rikki A RA LaMonte Michael J MJ Kelemen Linda E LE Risch Harvey A HA Eng Kevin H KH Minlikeeva Albina N AN Hong Chi-Chen CC Szender J Brian JB Sucheston-Campbell Lara L Joseph Janine M JM Berchuck Andrew A Chang-Claude Jenny J Cramer Daniel W DW DeFazio Anna A Diergaarde Brenda B Dörk Thilo T Doherty Jennifer A JA Edwards Robert P RP Fridley Brooke L BL Friel Grace G Goode Ellen L EL Goodman Marc T MT Hillemanns Peter P Hogdall Estrid E Hosono Satoyo S Kelley Joseph L JL Kjaer Susanne K SK Klapdor Rüdiger R Matsuo Keitaro K Odunsi Kunle K Nagle Christina M CM Olsen Catherine M CM Paddock Lisa E LE Pearce Celeste L CL Pike Malcolm C MC Rossing Mary A MA Schmalfeldt Barbara B Segal Brahm H BH Szamreta Elizabeth A EA Thompson Pamela J PJ Tseng Chiu-Chen CC Vierkant Robert R Schildkraut Joellen M JM Wentzensen Nicolas N Wicklund Kristine G KG Winham Stacey J SJ Wu Anna H AH Modugno Francesmary F Ness Roberta B RB Jensen Allan A Webb Penelope M PM Terry Kathryn K Bandera Elisa V EV Moysich Kirsten B KB

British journal of cancer 20160614 1

<h4>Background</h4>Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.<h4>Methods</h4>Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, w ...[more]

PMID: 27299959

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Project description:PURPOSE:Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated. METHODS:Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, overweight/obesity weight, and physical inactivity and overall survival (OS) as well as progression-free survival (PFS) among women diagnosed with invasive epithelial ovarian carcinoma (n?=?7,022). Using age- and stage-adjusted Cox proportional hazards regression models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) associated with joint exposure to these factors. RESULTS:Combined exposure to current smoking, overweight/obesity, and physical inactivity prior to diagnosis was associated with a significantly increased risk of mortality compared to women who never smoked, had normal body mass index (BMI), and were physically active (HR?=?1.37; 95% CI 1.10-1.70). The association for a joint exposure to these factors exceeded that of each exposure individually. In fact, exposure to both current smoking and overweight/obesity, and current smoking and physical inactivity was also associated with increased risk of death (HR?=?1.28; 95% CI 1.08-1.52, and HR?=?1.26; 95% CI 1.04-1.54, respectively). The associations were of a similar magnitude when former smoking was assessed in combination with the other exposures and when excessive weight was limited to obesity only. No significant associations were observed between joint exposure to any of these factors and PFS. CONCLUSIONS:Joint exposure to smoking, excessive weight, and physical inactivity may negatively impact survival of ovarian cancer patients. These results suggest the importance of examining the combined effect of lifestyle factors on ovarian cancer patients' survival.

Dataset Information

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Background

Methods

Results

Conclusion

Publications

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Similar Datasets

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