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ABSTRACT: Objectives
Non-alcoholic fatty liver disease is one of the most prevalent liver diseases and increases the risk of fibrosis and cirrhosis. Current standard treatment focuses on lifestyle interventions. The primary aim of this study was to assess the effects of a short-term low-calorie diet on hepatic steatosis, using the controlled attenuation parameter (CAP) as quantitative tool.Methods
In this prospective observational study, 60 patients with hepatic steatosis were monitored during a hypocaloric high-fiber, high-protein diet containing 1,000?kcal/day. At baseline and after 14 days, we measured hepatic fat contents using CAP during transient elastography, body composition with bioelectrical impedance analysis, and serum liver function tests and lipid profiles using standard clinical-chemical assays.Results
The median age was 56 years (25-78 years); 51.7% were women and median body mass index was 31.9?kg/m(2) (22.4-44.8?kg/m(2)). After 14 days, a significant CAP reduction (14.0%; P<0.001) was observed from 295?dB/m (216-400?dB/m) to 266?dB/m (100-353?dB/m). In parallel, body weight decreased by 4.6% (P<0.001), of which 61.9% was body fat. In addition, liver stiffness (P=0.002), ?-GT activities, and serum lipid concentrations decreased (all P<0.001).Conclusions
This study shows for the first time that non-invasive elastography can be used to monitor rapid effects of dietary treatment for hepatic steatosis. CAP improvements occur after only 14 days on short-term low-calorie diet, together with reductions of body composition parameters, serum lipids, and liver enzymes, pointing to the dynamics of hepatic lipid turnover.
SUBMITTER: Arslanow A
PROVIDER: S-EPMC4931593 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Clinical and translational gastroenterology 20160616 6
<h4>Objectives</h4>Non-alcoholic fatty liver disease is one of the most prevalent liver diseases and increases the risk of fibrosis and cirrhosis. Current standard treatment focuses on lifestyle interventions. The primary aim of this study was to assess the effects of a short-term low-calorie diet on hepatic steatosis, using the controlled attenuation parameter (CAP) as quantitative tool.<h4>Methods</h4>In this prospective observational study, 60 patients with hepatic steatosis were monitored du ...[more]