Ontology highlight
ABSTRACT:
SUBMITTER: Tuohy VK
PROVIDER: S-EPMC4931621 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tuohy Vincent K VK Jaini Ritika R Johnson Justin M JM Loya Matthew G MG Wilk Dennis D Downs-Kelly Erinn E Mazumder Suparna S
Cancers 20160616 6
We have proposed that safe and effective protection against the development of adult onset cancers may be achieved by vaccination against tissue-specific self-proteins that are "retired" from expression at immunogenic levels in normal tissues as we age, but are overexpressed in emerging tumors. α-Lactalbumin is an example of a "retired" self-protein because its expression in normal tissues is confined exclusively to the breast during late pregnancy and lactation, but is also expressed in the vas ...[more]