Ontology highlight
ABSTRACT:
SUBMITTER: Frank GA
PROVIDER: S-EPMC4931865 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Frank Gabriel A GA Shukla Suneet S Rao Prashant P Borgnia Mario J MJ Bartesaghi Alberto A Merk Alan A Mobin Aerfa A Esser Lothar L Earl Lesley A LA Gottesman Michael M MM Xia Di D Ambudkar Suresh V SV Subramaniam Sriram S
Molecular pharmacology 20160511 1
The multidrug transporter P-glycoprotein (P-gp, ABCB1) is an ATP-dependent pump that mediates the efflux of structurally diverse drugs and xenobiotics across cell membranes, affecting drug pharmacokinetics and contributing to the development of multidrug resistance. Structural information about the conformational changes in human P-gp during the ATP hydrolysis cycle has not been directly demonstrated, although mechanistic information has been inferred from biochemical and biophysical studies con ...[more]