Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen DP
PROVIDER: S-EPMC4932181 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature communications 20160701
Cas9-based RNA-guided nuclease (RGN) has emerged to be a versatile method for genome editing due to the ease of construction of RGN reagents to target specific genomic sequences. The ability to control the activity of Cas9 with a high temporal resolution will facilitate tight regulation of genome editing processes for studying the dynamics of transcriptional regulation or epigenetic modifications in complex biological systems. Here we show that fusing ligand-binding domains of nuclear receptors ...[more]