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Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data.

ABSTRACT: Lung-specific genes play critically important roles in lung development, lung physiology, and pathogenesis of lung-associated diseases. We performed a meta-analysis of multiple tissue RNA-seq data to identify lung-specific genes in order to better investigate their lung-specific functions and pathological roles. We identified 83 lung-specific genes consisting of 62 protein-coding genes, five pseudogenes and 16 noncoding RNA genes. About 49.4% of lung-specific genes were implicated in the pathogenesis of lung diseases and 21.7% were involved with lung development. The identification of genes with enriched expression in the lung will facilitate the elucidation of lung-specific functions and their roles in disease pathogenesis.

SUBMITTER: Xiong M

PROVIDER: S-EPMC4932457 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data.

Xiong Min M Heruth Daniel P DP Zhang Li Qin LQ Ye Shui Qing SQ

FEBS open bio 20160616 7

Lung-specific genes play critically important roles in lung development, lung physiology, and pathogenesis of lung-associated diseases. We performed a meta-analysis of multiple tissue RNA-seq data to identify lung-specific genes in order to better investigate their lung-specific functions and pathological roles. We identified 83 lung-specific genes consisting of 62 protein-coding genes, five pseudogenes and 16 noncoding RNA genes. About 49.4% of lung-specific genes were implicated in the pathoge ...[more]

PMID: 27398317

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