Ontology highlight
ABSTRACT:
SUBMITTER: Zhu R
PROVIDER: S-EPMC4932834 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20151222 5
Controversy regarding the number and function of ligand binding sites in neurotransmitter/sodium symporters arose from conflicting data in crystal structures and molecular pharmacology. Here, we have designed novel tools for atomic force microscopy that directly measure the interaction forces between the serotonin transporter (SERT) and the S- and R-enantiomers of citalopram on the single molecule level. This approach is based on force spectroscopy, which allows for the extraction of dynamic inf ...[more]