Ontology highlight
ABSTRACT:
SUBMITTER: Acevedo J
PROVIDER: S-EPMC4933228 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Acevedo Julyana J Yan Shan S Michael W Matthew WM
The Journal of biological chemistry 20160426 25
A critical event for the ability of cells to tolerate DNA damage and replication stress is activation of the ATR kinase. ATR activation is dependent on the BRCT (BRCA1 C terminus) repeat-containing protein TopBP1. Previous work has shown that recruitment of TopBP1 to sites of DNA damage and stalled replication forks is necessary for downstream events in ATR activation; however, the mechanism for this recruitment was not known. Here, we use protein binding assays and functional studies in Xenopus ...[more]