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Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.


ABSTRACT: Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation.

SUBMITTER: Dai J 

PROVIDER: S-EPMC4933315 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.

Dai Jingqiu J   Sorribas Analia A   Yoshida Wesley Y WY   Kelly Michelle M   Williams Philip G PG  

Journal of natural products 20100901 9


Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation. ...[more]

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