Ontology highlight
ABSTRACT:
SUBMITTER: Dai J
PROVIDER: S-EPMC4933315 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Dai Jingqiu J Sorribas Analia A Yoshida Wesley Y WY Kelly Michelle M Williams Philip G PG
Journal of natural products 20100901 9
Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation. ...[more]