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Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.


ABSTRACT: A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

SUBMITTER: Pham CD 

PROVIDER: S-EPMC4900817 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.

Pham Cong-Dat CD   Hartmann Rudolf R   Böhler Philip P   Stork Björn B   Wesselborg Sebastian S   Lin Wenhan W   Lai Daowan D   Proksch Peter P  

Organic letters 20131213 1


A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes. ...[more]

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