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Ligand-Enabled Stereoselective ?-C(sp(3))-H Fluorination: Synthesis of Unnatural Enantiopure anti-?-Fluoro-?-amino Acids.

ABSTRACT: A quinoline-based ligand was shown to promote palladium-catalyzed ?-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated ?-amino acids were obtained through sequential ?-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.

SUBMITTER: Zhu RY

PROVIDER: S-EPMC4934178 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Ligand-Enabled Stereoselective β-C(sp(3))-H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-amino Acids.

Zhu Ru-Yi RY Tanaka Keita K Li Gen-Cheng GC He Jian J Fu Hai-Yan HY Li Su-Hua SH Yu Jin-Quan JQ

Journal of the American Chemical Society 20150527 22

A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine. ...[more]

PMID: 26001406

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