Ontology highlight
ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC4179246 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140301 6176
The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C(sp(3))-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp(3))-H arylation using pyridine and quinoline derivatives: The former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a m ...[more]