Ontology highlight
ABSTRACT:
SUBMITTER: Cereda M
PROVIDER: S-EPMC4935966 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Cereda Matteo M Gambardella Gennaro G Benedetti Lorena L Iannelli Fabio F Patel Dominic D Basso Gianluca G Guerra Rosalinda F RF Mourikis Thanos P TP Puccio Ignazio I Sinha Shruti S Laghi Luigi L Spencer Jo J Rodriguez-Justo Manuel M Ciccarelli Francesca D FD
Nature communications 20160705
Synchronous colorectal cancers (syCRCs) are physically separated tumours that develop simultaneously. To understand how the genetic and environmental background influences the development of multiple tumours, here we conduct a comparative analysis of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire dissimilar somatic alterations, and have different clone composition. This inter- and intratumour heterogeneity must be considered in the selection of therapy ...[more]